Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels
Author:
Affiliation:
1. Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10065, United States
Funder
Cure Alzheimer's Fund
Fisher Center for Alzheimer's Research Foundation
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00425
Reference35 articles.
1. Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update
2. The protein kinase CK1: Inhibition, activation, and possible allosteric modulation
3. Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain
4. Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions
5. A New Molecular Link between the Fibrillar and Granulovacuolar Lesions of Alzheimer's Disease
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