Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization-Reference-Cited by-同舟云学术

Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization

Published:2024-01-31 Issue:2 Volume:19 Page:266-279
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Bauer Nicolas¹²^ORCID,Balourdas Dimitrios-Ilias¹²^ORCID,Schneider Joel R.³⁴,Zhang Xin³⁴,Berger Lena M.¹²^ORCID,Berger Benedict-Tilman¹²^ORCID,Schwalm Martin P.¹²⁵^ORCID,Klopp Nick A.³⁴,Siveke Jens T.³⁴,Knapp Stefan¹²⁵^ORCID,Joerger Andreas C.¹²^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany

2. Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany

3. Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany

4. Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK Partner Site Essen) and German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany

5. German Translational Cancer Network (DKTK) Site Frankfurt/Mainz, Frankfurt am Main 60438, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Deutsches Krebsforschungszentrum

Deutsche Forschungsgemeinschaft

Frankfurt Cancer Institute

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00427

Reference60 articles.

1. Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer

2. Targeting the cancer epigenome for therapy

3. Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends

4. BET bromodomain inhibitors

5. Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight

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