Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε-Reference-Cited by-同舟云学术

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε

Published:2024-05-23 Issue:11 Volume:67 Page:8609-8629
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

de Souza Gama Fernando H.¹,Dutra Luiz A.²^ORCID,Hawgood Michael³⁴^ORCID,dos Reis Caio Vinícius²,Serafim Ricardo A. M.²^ORCID,Ferreira Marcos A.¹,Teodoro Bruno V. M.¹,Takarada Jéssica Emi²,Santiago André S.²^ORCID,Balourdas Dimitrios-Ilias⁵⁶^ORCID,Nilsson Ann-Sofie³⁴,Urien Bruno³⁴,Almeida Vitor M.²,Gileadi Carina²,Ramos Priscila Z.²,Salmazo Anita²,Vasconcelos Stanley N. S.²,Cunha Micael R.²^ORCID,Mueller Susanne⁵⁶^ORCID,Knapp Stefan⁵⁶^ORCID,Massirer Katlin B.²^ORCID,Elkins Jonathan M.²^ORCID,Gileadi Opher²,Mascarello Alessandra¹,Lemmens Bennie B. L. G.³⁴^ORCID,Guimarães Cristiano R. W.¹,Azevedo Hatylas¹^ORCID,Couñago Rafael M.²^ORCID

Affiliation:

1. Aché Laboratórios Farmacêuticos S.A., Guarulhos, São Paulo 07034-904, Brazil

2. Centro de Química Medicinal, Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Av. Dr. André Tosello 550, 13083-886 Campinas, São Paulo Brazil

3. Science for Life Laboratory, Sweden, Tomtebodavägen 23A, 17165 Solna, Sweden

4. Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden

5. Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, Frankfurt am Main 60438, Germany

6. Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Str. 15, Frankfurt am Main 60438, Germany

Funder

Svenska Forskningsr??det Formas

Vetenskapsr??det

Minist??rio da Ci??ncia, Tecnologia e Inova????o

Structural Genomics Consortium

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

Cancerfonden

Karolinska Institutet

Mark Foundation For Cancer Research

Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior

Publisher

American Chemical Society (ACS)