Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3-Reference-Cited by-同舟云学术

Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3

Published:2024-03-21 Issue:4 Volume:19 Page:962-972
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Zhao Heng¹,Kumar Praveen²,Sobreira Tiago Jose Paschoal²,Smith Mackenzie¹,Novick Steven²,Johansson Anders³^ORCID,Luchniak Anna⁴,Zhang Andrew¹^ORCID,Woollard Kevin J⁵,Larsson Niklas⁶,Kawatkar Aarti¹^ORCID

Affiliation:

1. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, 02451 Waltham, Massachusetts, United States

2. Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, 02451 Waltham, Massachusetts, United States

3. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43183 Mölndal, Sweden

4. Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, 43183 Mölndal, Sweden

5. Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, CB2 OAA Cambridge, U.K.

6. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, 43183 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00777

Reference64 articles.

1. The Inflammasomes and Autoinflammatory Syndromes

2. Inflamm-aging: An Evolutionary Perspective on Immunosenescence

3. Drivers of age-related inflammation and strategies for healthspan extension

4. Targeting the NLRP3 inflammasome in inflammatory diseases

5. NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics