Interaction vs Preorganization in Enzyme Catalysis. A Dispute That Calls for Resolution
Author:
Affiliation:
1. Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States
2. Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900 Brazil
Funder
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico
Funda??o de Amparo ? Pesquisa e Inova??o do Estado de Santa Catarina
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Instituto Nacional de Ci?ncia e Tecnologia de Cat?lise em Sistemas Moleculares e Nanoestruturados
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.8b01029
Reference41 articles.
1. Misunderstanding the preorganization concept can lead to confusions about the origin of enzyme catalysis
2. Transforming a Stable Amide into a Highly Reactive One: Capturing the Essence of Enzymatic Catalysis
3. Multiscale Modeling of Biological Functions: From Enzymes to Molecular Machines (Nobel Lecture)
4. Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization
5. Electrostatic Basis for Enzyme Catalysis
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