Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling

Author:

Atxabal Unai1ORCID,Nycholat Corwin2,Pröpster Johannes M.3,Fernández Andrea1,Oyenarte Iker1,Lenza Maria Pia1,Franconetti Antonio1ORCID,Soares Cátia O.45,Coelho Helena45ORCID,Marcelo Filipa45,Schubert Mario36ORCID,Paulson James C.2ORCID,Jiménez-Barbero Jesús1789ORCID,Ereño-Orbea June17ORCID

Affiliation:

1. Chemical Glycobiology Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain

2. Departments of Molecular Medicine and Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

3. Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland

4. Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal

5. UCIBIO, Department of Chemistry, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal

6. Department of Biosciences and Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria

7. Ikerbasque, Basque Foundation for Science, Euskadi Pl., 5, 48009 Bilbao, Biscay, Spain

8. Department of Organic and Inorganic Chemistry, Faculty of Science and Technology, University of the Basque Country, EHU-UPV, 48940 Leioa, Bizkaia, Spain

9. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain

Funder

Agencia Estatal de Investigaci?n

H2020 Marie Sklodowska-Curie Actions

European Cooperation in Science and Technology

Funda??o para a Ci?ncia e a Tecnologia

H2020 European Research Council

Publisher

American Chemical Society (ACS)

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