Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study-Reference-Cited by-同舟云学术

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

Published:2016-04-08 Issue:6 Volume:11 Page:1693-1701
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Schiebel Johannes¹,Radeva Nedyalka¹,Krimmer Stefan G.¹,Wang Xiaojie¹,Stieler Martin¹,Ehrmann Frederik R.¹,Fu Kan¹,Metz Alexander¹,Huschmann Franziska U.¹²,Weiss Manfred S.²,Mueller Uwe²,Heine Andreas¹,Klebe Gerhard¹

Affiliation:

1. Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany

2. Helmholtz-Zentrum Berlin für Materialien und Energie, HZB, BESSY II, Abteilung Makromolekulare Kristallographie, Albert-Einstein-Str. 15, 12489 Berlin, Germany

Funder

Bundesministerium für Bildung und Forschung

European Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.5b01034

Reference60 articles.

1. Fragment-Based Approaches in Drug Discovery and Chemical Biology

2. The 'rule of three' for fragment-based drug discovery: where are we now?