Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin

Author:

Wyche Thomas P.1ORCID,Alvarenga René F. Ramos1,Piotrowski Jeff S.2,Duster Megan N.3,Warrack Simone R.3,Cornilescu Gabriel4ORCID,De Wolfe Travis J.5ORCID,Hou Yanpeng1,Braun Doug R.1,Ellis Gregory A.1,Simpkins Scott W.6,Nelson Justin6,Myers Chad L.6,Steele James5,Mori Hirotada7,Safdar Nasia3,Markley John L.4ORCID,Rajski Scott R.1,Bugni Tim S.1ORCID

Affiliation:

1. Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin—Madison, Madison, Wisconsin 53705, United States

2. Yumanity Therapeutics, Cambridge, Massachusetts 02139, United States

3. Department of Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53705, United States

4. National Magnetic Resonance Facility at Madison, Department of Biochemistry, University of Wisconsin—Madison, Madison, Wisconsin 53706, United States

5. Department of Food Science, University of Wisconsin—Madison, Madison, Wisconsin 53706, United States

6. Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States

7. Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630-0101, Japan

Funder

National Center for Advancing Translational Sciences

Division of Biological Infrastructure

Biological and Environmental Research

Ministry of Education, Culture, Sports, Science and Technology

National Human Genome Research Institute

Japan Society for the Promotion of Science

National Institute of General Medical Sciences

U.S. Department of Agriculture

School of Pharmacy, University of Wisconsin-Madison

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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