Rediscovery of Tetronomycin as a Broad-Spectrum and Potent Antibiotic against Drug-Resistant Gram-Positive Bacteria

Author:

Kimishima Aoi12,Tsuruoka Iori1,Kanto Hiroki1,Tsutsumi Hayama12,Arima Naoaki3ORCID,Sakai Kazunari3,Sugamata Miho12,Matsui Hidehito12,Watanabe Yoshihiro12ORCID,Iwatsuki Masato12ORCID,Honsho Masako12,Naher Kamrun2,Inahashi Yuki12,Hanaki Hideaki123,Asami Yukihiro12ORCID

Affiliation:

1. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

2. O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

3. Tokyo New Drug Research Laboratories, Pharmaceutical Business Unit, Kowa Company, Ltd., 2-17-43 Noguchicho, Higashimurayama, Tokyo 189-0022, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference19 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

2. Vancomycin Revisited – 60 Years Later

3. CDC’s Antibiotic Resistance Threats in the United States, 2019 ( 2019 AR Threats Report) Available at: https://www.cdc.gov/drugresistance/biggest-threats.html

4. Tetronomycin, a novel polyether of unusual structure.

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