Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein–Protein Interaction-Reference-Cited by-同舟云学术

Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein–Protein Interaction

Published:2024-01-20 Issue: Volume: Page:
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Jha Ram¹²^ORCID,Kinna Alexander¹,Hotblack Alastair²,Bughda Reyisa¹,Bulek Anna¹,Gannon Isaac¹,Ilca Tudor¹,Allen Christopher¹^ORCID,Lamb Katarina¹,Dolor Abigail¹,Scott Ian¹,Parekh Farhaan¹,Sillibourne James¹^ORCID,Cordoba Shaun¹,Onuoha Shimobi¹,Thomas Simon¹,Ferrari Mathieu¹,Pule Martin¹²

Affiliation:

1. Autolus Therapeutics, London W12 7FP, U.K.

2. Research Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, U.K.

Funder

Autolus Ltd

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00521

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1. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

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4. Remote control of therapeutic T cells through a small molecule–gated chimeric receptor

5. Design of chimeric antigen receptors with integrated controllable transient functions

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