Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis-Reference-Cited by-同舟云学术

Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis

Published:2017-10-09 Issue:11 Volume:12 Page:2779-2787
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Bury Priscila dos Santos¹,Huang Fanglu²^ORCID,Li Sicong³,Sun Yuhui³^ORCID,Leadlay Peter F.²,Dias Marcio Vinicius Bertacine¹^ORCID

Affiliation:

1. Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil

2. Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom

3. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, People’s Republic of China

Funder

Medical Research Council

Ministry of Science and Technology of the People's Republic of China

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

National Natural Science Foundation of China

Translational Medical Research Fund, Wuhan University

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.7b00466

Reference48 articles.

1. Architectures, mechanisms and molecular evolution of natural product methyltransferases

2. Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain

3. Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin

4. Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

5. Novel Glycopeptide Antibiotics: N-Alkylated Derivatives Active Against Vancomycin-Resistant Enterococci.

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