Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism-Reference-Cited by-同舟云学术

Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

Published:2022-04-04 Issue:4 Volume:17 Page:816-821
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Dahms Sven O.¹^ORCID,Schnapp Gisela²,Winter Martin³,Büttner Frank H.³,Schlepütz Marco⁴,Gnamm Christian²^ORCID,Pautsch Alexander²,Brandstetter Hans¹

Affiliation:

1. Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Straße 34, A-5020 Salzburg, Austria

2. Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH& Co KG, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany

3. Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH& Co KG, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany

4. Department of I&R Research, R&D Project Management and Development Strategies, Boehringer Ingelheim Pharma GmbH& Co KG, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany

Funder

Austrian Science Fund

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00103

Reference27 articles.

1. Proprotein Convertases in Health and Disease

2. The biology and therapeutic targeting of the proprotein convertases

3. Molecular and Enzymatic Properties of Furin, a Kex2-Like Endoprotease Involved in Precursor Cleavage at Arg-X-Lys/Arg-Arg Sites1

4. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

5. Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

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