W254 in furin functions as a molecular gate promoting anti-viral drug binding: Elucidation of putative drug tunneling and docking by non-equilibrium molecular dynamics
Author:
Publisher
Elsevier BV
Subject
Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology
Reference65 articles.
1. Dichlorophenylpyridine-based molecules inhibit furin through an induced-fit mechanism;Dahms;ACS Chem Biol,2022
2. Furin at the cutting edge: from protein traffic to embryogenesis and disease;Thomas;Nat Rev Mol Cell Biol,2002
3. The endoproteinase furin contains two essential Ca2+ions stabilizing its N-terminus and the unique S1 specificity pocket;Than;Acta Crystallogr Sect D Biol Crystallogr,2005
4. Furin‐mediated protein processing in infectious diseases and cancer;Braun;Clin Transl Immunol,2019
5. Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality;Fernandez;J Intern Med,2018
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