Structural Insights into PROTAC-Mediated Degradation of Bcl-xL-Reference-Cited by-同舟云学术

Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

Published:2020-07-22 Issue:9 Volume:15 Page:2316-2323
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Chung Chun-wa¹^ORCID,Dai Han²,Fernandez Esther³^ORCID,Tinworth Christopher P.³^ORCID,Churcher Ian³^ORCID,Cryan Jenni³,Denyer Jane³,Harling John D.³^ORCID,Konopacka Agnieszka³,Queisser Markus A.³^ORCID,Tame Christopher J.³,Watt Gillian³,Jiang Fan⁴,Qian Dongming⁴,Benowitz Andrew B.³^ORCID

Affiliation:

1. Protein, Cellular & Structural Sciences, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

2. Protein Degradation Group, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

3. Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

4. Viva Biotech, Ltd., 334 Aidisheng Rd., Zhangjiang High-tech Park, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00266

Reference25 articles.

1. The role of the Bcl-2 protein family in cancer

2. BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis: Figure 1.

3. A delicate balance – The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics

4. Apoptosis: A Review of Programmed Cell Death

5. Moderate Activation of the Apoptosis Inhibitor bcl-xL Worsens the Prognosis in Pancreatic Cancer

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