Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors-Reference-Cited by-同舟云学术

Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors

Published:2020-02-04 Issue:2 Volume:15 Page:325-333
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Howard Ryan T.¹,Hemsley Paul²,Petteruti Philip³,Saunders Charlie N.¹,Molina Bermejo Javier A.¹,Scott James S.²^ORCID,Johannes Jeffrey W.³^ORCID,Tate Edward W.¹^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, United Kingdom

2. Oncology, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

3. Oncology, R&D, AstraZeneca, Boston, Waltham, Massachusetts 02451, United States

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00963

Reference40 articles.

1. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

2. Family-wide analysis of poly(ADP-ribose) polymerase activity

3. Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

4. The role of poly ADP-ribosylation in the first wave of DNA damage response

5. PARP-1 and gene regulation: Progress and puzzles

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