A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction-Reference-Cited by-同舟云学术

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction

Published:2016-10-17 Issue:12 Volume:11 Page:3310-3318
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Surmiak Ewa¹,Twarda-Clapa Aleksandra²³,Zak Krzysztof M.²³,Musielak Bogdan¹,Tomala Marcin D.¹,Kubica Katarzyna¹,Grudnik Przemyslaw²,Madej Mariusz²³,Jablonski Mateusz¹,Potempa Jan²³,Kalinowska-Tluscik Justyna¹,Dömling Alexander⁴,Dubin Grzegorz²³,Holak Tad A.¹³

Affiliation:

1. Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland

2. Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland

3. Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland

4. Faculty of Mathematics and Natural Sciences, Department of Pharmacy, University of Groningen, 9713AV Groningen, The Netherlands

Funder

European Commission

Narodowe Centrum Nauki

Directorate-General for Research and Innovation

Fundacja na rzecz Nauki Polskiej

National Institute of General Medical Sciences

Wydzial Biochemii, Biofizyki i Biotechnologii, Uniwersytet Jagiellonski w Krakowie

European Regional Development Fund

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.6b00596

Reference50 articles.

1. Awakening guardian angels: drugging the p53 pathway

2. Translating p53 into the clinic

3. The role of ubiquitin modification in the regulation of p53

4. MDM2, MDMX and p53 in oncogenesis and cancer therapy

5. Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer;Current Medicinal Chemistry;2023-10

2. Rational Design, Synthesis, Separation, and Characterization of New Spiroxindoles Combined with Benzimidazole Scaffold as an MDM2 Inhibitor;Separations;2023-03-24

3. Nutlin‐3a‐aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent‐Exposed Methylene Group;ChemBioChem;2023-02-16

4. Stable organic electrochemical neurons based on p-type and n-type ladder polymers;Materials Horizons;2023

5. Recent advances in the pharmacological targeting of ubiquitin-regulating enzymes in cancer;Seminars in Cell & Developmental Biology;2022-12