Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm-Reference-Cited by-同舟云学术

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

Published:2020-01-28 Issue:3 Volume:15 Page:657-668
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Bauer Matthias R.¹^ORCID,Krämer Andreas²³,Settanni Giovanni⁴^ORCID,Jones Rhiannon N.⁵,Ni Xiaomin²³,Khan Tareque Raysa⁵,Fersht Alan R.¹,Spencer John⁵^ORCID,Joerger Andreas C.²³^ORCID

Affiliation:

1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom

2. Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany

3. Buchmann Institute for Molecular Life Sciences and Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany

4. Physics Department, Johannes Gutenberg University, Staudingerweg 7, 55099 Mainz, Germany

5. Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QJ, United Kingdom

Funder

Worldwide Cancer Research

Deutsche Forschungsgemeinschaft

Max-Planck Graduate Center, University of Mainz

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00748

Reference57 articles.

1. The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

2. Drugging the p53 pathway: understanding the route to clinical efficacy

3. How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

4. Structure–function–rescue: the diverse nature of common p53 cancer mutants

5. Mutant p53: one name, many proteins

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