The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α-Reference-Cited by-同舟云学术

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α

Published:2012-09-11 Issue:18 Volume:55 Page:8007-8020
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heffron Timothy P.¹,Salphati Laurent¹,Alicke Bruno¹,Cheong Jonathan¹,Dotson Jennafer¹,Edgar Kyle¹,Goldsmith Richard¹,Gould Stephen E.¹,Lee Leslie B.¹,Lesnick John D.¹,Lewis Cristina¹,Ndubaku Chudi¹,Nonomiya Jim¹,Olivero Alan G.¹,Pang Jodie¹,Plise Emile G.¹,Sideris Steve¹,Trapp Sean¹,Wallin Jeffrey¹,Wang Lan¹,Zhang Xiaolin¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300867c

Reference23 articles.

1. Targeting the phosphoinositide 3-kinase pathway in cancer

2. mTOR signaling in glioblastoma: lessons learned from bench to bedside

3. Comprehensive genomic characterization defines human glioblastoma genes and core pathways