A Practical and Robust Process to Produce SB-214857, Lotrafiban, ((2S)-7-(4,4‘-Bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1, 4-Benzodiazepine-2-acetic Acid) Utilising an Enzymic Resolution as the Final Step-Reference-Cited by-同舟云学术

A Practical and Robust Process to Produce SB-214857, Lotrafiban, ((2S)-7-(4,4‘-Bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1, 4-Benzodiazepine-2-acetic Acid) Utilising an Enzymic Resolution as the Final Step

Published:2002-06-11 Issue:4 Volume:6 Page:488-491
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Walsgrove Timothy C.¹,Powell Lawson¹,Wells Andy¹

Affiliation:

1. Chemical Development, GlaxoSmithKline Pharmaceuticals, Old Powder Mills, near Leigh, Tonbridge, Kent TN11 9AN, England

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op025508w

Reference6 articles.

1. Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

2. An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate

3. An Alternative Synthesis of a Potent GPIIb/IIIa Receptor Antagonist

4. A New and Convergent Synthesis of (2S)-7-(4,4‘-Bipiperidinylcarbonyl)-2,3,4,5- tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic Acid Using a Palladium-Catalysed Aminocarbonylation Reaction

5. One Biocatalyst–Many Applications: The Use of Candida Antarctica B-Lipase in Organic Synthesis

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of Benzotriazepin-1-ones via Decarboxylative [4 + 3]-Annulation of Isatoic Anhydrides with Nitrile Imines;The Journal of Organic Chemistry;2023-05-17

2. Value Addition to Chemical Compounds Through Biotransformation;Industrial Microbiology and Biotechnology;2022

3. Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods;Chemical Reviews;2021-11-30

4. Streamlining Design, Engineering, and Applications of Enzymes for Sustainable Biocatalysis;ACS Sustainable Chemistry & Engineering;2021-06-09

5. HFIP‐Mediated Decarboxylative [4+3]‐Annulation of Azaoxyallyl Cations with Isatoic Anhydride;Advanced Synthesis & Catalysis;2020-05-29