Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives-Reference-Cited by-同舟云学术

Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Published:2011-06-20 Issue:13 Volume:54 Page:4735-4751
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nishimura Nobuko¹,Siegmund Aaron¹,Liu Longbin¹,Yang Kevin¹,Bryan Marian C.¹,Andrews Kristin L.¹,Bo Yunxin¹,Booker Shon K.¹,Caenepeel Sean¹,Freeman Daniel¹,Liao Hongyu¹,McCarter John¹,Mullady Erin L.¹,San Miguel Tisha¹,Subramanian Raju¹,Tamayo Nuria¹,Wang Ling¹,Whittington Douglas A.¹,Zalameda Leeanne¹,Zhang Nancy¹,Hughes Paul E.¹,Norman Mark H.¹

Affiliation:

1. Department of Chemistry Research and Discovery, ‡Department of Oncology Research, §Pharmacokinetics & Drug Metabolism, ∥Department of Molecular Structure, and ⊥Department of High-Throughput Screening/Molecular Pharmacology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200386s

Reference18 articles.

1. The Phosphoinositide 3-Kinase Pathway

2. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

3. Targeting the phosphoinositide 3-kinase pathway in cancer

4. Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

5. Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

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