Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening-Reference-Cited by-同舟云学术

Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening

Published:2023-07-13 Issue:14 Volume:66 Page:9495-9518
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Deng Dexin¹,Yang Yingxue¹,Zou Yurong²,Liu Kongjun¹,Zhang Chufeng¹,Tang Minghai¹,Yang Tao¹^ORCID,Chen Yong¹,Yuan Xue¹,Guo Yong¹,Zhang Shunjie¹,Si Wenting¹,Peng Bin¹,Xu Qing¹,He Wen¹,Xu Dingguo²^ORCID,Xiang Mingli¹,Chen Lijuan¹³^ORCID

Affiliation:

1. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China

2. MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu, Sichuan610064, P.R. China

3. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu610041, China

Funder

West China Hospital, Sichuan University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00082