Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Author:

Chong Pek1,Sebahar Paul1,Youngman Michael1,Garrido Dulce1,Zhang Huichang1,Stewart Eugene L.1,Nolte Robert T.1,Wang Liping1,Ferris Robert G.1,Edelstein Mark1,Weaver Kurt1,Mathis Amanda1,Peat Andrew1

Affiliation:

1. GlaxoSmithKline Research & Development, 5 Moore Drive, Research Triangle Park, North Carolina 27709, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference24 articles.

1. Efavirenz: a review

2. Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

3. Antiviral Activity of GW678248, a Novel Benzophenone Nonnucleoside Reverse Transcriptase Inhibitor

4. bAndrews, C. W.; Chan, J. H.; Freeman, G. A.; Romines, K. R.; Tidwell, J. H.Benzophenones as inhibitors of reverse transcriptase. PCT Int. Appl. WO 2001017982A1, 2001.

5. Becker, S.; Lelezari, J.; Walworth, C.; Kumar, P.; Cade, J.; Ng-Cashin, J.; Kim, Y.; Scott, J.; St. Clair, M.; Jones, L.; Symonds, W.Antiviral Activity and Safety of GW695634, a Novel Next Generation NNRTI in NNRTI-resistant HIV-1 Infected Patients. 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, Brazil, 2005, WePe6.2C03.

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