Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine-3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition-Reference-Cited by-同舟云学术

Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine-3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition

Published:2014-01-27 Issue:3 Volume:57 Page:733-758
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brown Dean G.¹,Bernstein Peter R.¹,Griffin Andrew²,Wesolowski Steve¹,Labrecque Denis²,Tremblay Maxime C.²,Sylvester Mark¹,Mauger Russell¹,Edwards Phillip D.¹,Throner Scott R.¹,Folmer James J.¹,Cacciola Joseph¹,Scott Clay¹,Lazor Lois A.¹,Pourashraf Mehrnaz¹,Santhakumar Vijayaratnam¹,Potts William M.¹,Sydserff Simon¹,Giguère Pascall³,Lévesque Carine³,Dasser Mohammed³,Groblewski Thierry²

Affiliation:

1. AstraZeneca CNS Discovery Research, 1800 Concord Pike, Wilmington, Delaware 19850, United States

2. AstraZeneca Montréal, 7171 Frédérick-Banting, Montréal, Québec H4S 1Z9, Canada

3. OmegaChem, 480 Rue Perreault, Saint-Romuald, Québec G6W 7 V6, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4014828

Reference46 articles.

1. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor