Regioselective synthesis of spirocyclic pyrrolines <i>via</i> a palladium-catalyzed Narasaka–Heck/C–H activation/[4 + 2] annulation cascade reaction-Reference-Cited by-同舟云学术

Regioselective synthesis of spirocyclic pyrrolines via a palladium-catalyzed Narasaka–Heck/C–H activation/[4 + 2] annulation cascade reaction

Published:2022 Issue:21 Volume:13 Page:6348-6354
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wei Wan-Xu¹,Kong Xiangtao²,Jiao Rui-Qiang¹,Li Xue-Song¹,Wang Cui-Tian¹,Li Yuke³^ORCID,Liang Yong-Min¹^ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

2. Henan Key Laboratory of New Optoelectronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, P. R. China

3. Department of Chemistry, Centre for Scientific Modeling and Computation, Chinese University of Hong Kong, Shatin, Hong Kong, P. R. China

Abstract

Readily available 2-chlorobenzoic acid or ethyl phenylpropiolate as the C2 insertion unit. High regioselectivity. Broad substrate scope. Mechanistic studies.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01887J

Reference97 articles.

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2. Ring Construction by Palladium(0)-Catalyzed C(sp3)–H Activation

3. Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality