Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)-Reference-Cited by-同舟云学术

Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)

Published:2010-05-13 Issue:11 Volume:53 Page:4481-4487
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Véniant Murielle M.¹,Hale Clarence¹,Hungate Randall W.²,Gahm Kyung²,Emery Maurice G.³,Jona Janan⁴,Joseph Smriti⁴,Adams Jeffrey²,Hague Andrew²,Moniz George²,Zhang Jiandong²,Bartberger Michael D.²,Li Vivian²,Syed Rashid²,Jordan Steven²,Komorowski Renée¹,Chen Michelle M.¹,Cupples Rod¹,Kim Ki Won¹,St. Jean David J.²,Johansson Lars⁵,Henriksson Martin A.⁵,Williams Meredith⁵,Vallgårda Jerk⁵,Fotsch Christopher²,Wang Minghan¹

Affiliation:

1. Departments of Metabolic Disorders

2. Chemistry Research and Development

3. PKDM

4. Pharmaceutics

5. Biovitrum AB, SE-112 76 Stockholm, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100242d