Development of a Practical Synthesis of a TORC1/2 Inhibitor: A Scalable Application of Memory of Chirality-Reference-Cited by-同舟云学术

Development of a Practical Synthesis of a TORC1/2 Inhibitor: A Scalable Application of Memory of Chirality

Published:2013-05-07 Issue:5 Volume:17 Page:829-837
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hicks Frederick¹,Hou Yongquan¹,Langston Marianne¹,McCarron Ashley¹,O’Brien Erin¹,Ito Tatsuya²,Ma Chunrong³,Matthews Chris³,O’Bryan Colin³,Provencal David³,Zhao Yuxin³,Huang Jie⁴,Yang Qiang⁴,Heyang Li⁵,Johnson Matthew⁵,Sitang Yan⁵,Yuqiang Liu⁵

Affiliation:

1. Process Chemistry Research and Development, Millennium: The Takeda Oncology Company, 35 Landsdowne Street, Cambridge, Massachusetts, 02139, United States

2. Chemical Development Laboratories, CMC Center, Takeda Pharmaceutical Company Limited, 17-85, Jusohonmachi 2-Chome, Yodogawa-Ku, Osaka 532-8686, Japan

3. Process Chemistry, Takeda California, 10410, United States Science Center Drive, San Diego, California 92121, United States

4. Chemical Development Department, AMRI, 21 Corporate Circle, Albany, New York 12203, United States

5. Asymchem Life Science, Tianjin 71 seventh Avenue TEDA, Tianjin, 300457, P.R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op300330f

Reference18 articles.

1. TOR signalling in bugs, brain and brawn

2. Upstream and downstream of mTOR

3. TOR Signaling in Growth and Metabolism

4. Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis

5. Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway

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