Total Synthesis of the Antiviral Marine Natural Product (−)-Hennoxazole A

Author:

Yokokawa Fumiaki1,Asano Toshinobu1,Shioiri Takayuki1

Affiliation:

1. Faculty of Pharmaceutical Sciences, Nagoya City University,Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference30 articles.

1. Hennoxazoles, bioactive bisoxazoles from a marine sponge

2. Bioactive compounds from marine sponges

3. Isolation and structure determination of diazonamides A and B, unusual cytotoxic metabolites from the marine ascidian Diazona chinensis

4. Muscoride A: A new oxazole peptide alkaloid from freshwater cyanobacterium Nostoc muscorum

5. Linked trisoxazole units have been found in some marine macrolides. (a) Ulapualides A and B (Roesener, J. A.; Scheuer, P. J.J. Am. Chem. Soc.1986,108, 846−847). (b) Halichondramides (Kernan, M. R.; Molinski, T. F.; Faulkner, J. D.J. Org. Chem.1988,53, 5014−5020). (c) Kabiramides A−E (Matsunaga, S.; Fusetani, N.; Hashimoto, K.; Koseki, K.; Noma, M.; Noguchi, H.; Sankawa, U.J. Org. Chem.1989,54, 1360−1363). (d) Jaspisamides A−C (Kobayashi, J.; Murata, O.; Shigemori, H.J. Nat. Prod.1993,56, 787−791). (e) Mycalolides (Matsunaga, S.; Sugawara, T.; Fusetani, N.J. Nat. Prod.1998,61, 1164−1167, and references therein).

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