Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency-Reference-Cited by-同舟云学术

Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency

Published:1999-10-08 Issue:22 Volume:42 Page:4584-4603
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brundish Derek¹,Bull Alice¹,Donovan Vera¹,Fullerton Joseph D.¹,Garman Sheila M.¹,Hayler Judy F.¹,Janus Diana¹,Kane Peter D.¹,McDonnell Mark¹,Smith Garrick P.¹,Wakeford Robert¹,Walker Clive V.¹,Howarth Graham¹,Hoyle William¹,Allen Mark C.¹,Ambler John¹,Butler Keith¹,Talbot Mark D.¹

Affiliation:

1. Department of Chemistry, Department of Biology, and Drug Discovery Support, Novartis Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K., and Ciba Central Research Laboratories, Hulley Road, Macclesfield, Cheshire SK10 2NX, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9811209

Reference59 articles.

1. Enhancing safety and outcomes with the newer antithrombotic and antiplatelet agents

2. New thrombin inhibitors in cardiovascular disease

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