Synthesis of the CETP Inhibitor Torcetrapib: The Resolution Route and Origin of Stereoselectivity in the Iminium Ion Cyclization-Reference-Cited by-同舟云学术

Synthesis of the CETP Inhibitor Torcetrapib: The Resolution Route and Origin of Stereoselectivity in the Iminium Ion Cyclization

Published:2006-03-16 Issue:3 Volume:10 Page:464-471
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Damon David B.¹,Dugger Robert W.¹,Magnus-Aryitey George¹,Ruggeri Roger B.¹,Wester Ronald T.¹,Tu Meihua¹,Abramov Yuriy¹

Affiliation:

1. Chemical Research and Development, Department of Medicinal Chemistry, Exploratory Medicinal Chemistry, Pfizer Global Research and Development, Groton Labs, Eastern Point Road, Groton, Connecticut 06340, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op060014a

Reference25 articles.

1. Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib

2. Synthesis of 2-CF3-Tetrahydroquinoline and Quinoline Derivatives from CF3-N-Aryl-aldimine

3. Synthesis of cis and trans 4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor

4. An Unexpected Incident with 4-Trifluoromethylaniline

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