Synthesis, Resolution, and Biological Evaluation of Atropisomeric (aR)- and (aS)-16-Methyllamellarins N: Unique Effects of the Axial Chirality on the Selectivity of Protein Kinases Inhibition

Author:

Yoshida Kenyu1,Itoyama Ryosuke1,Yamahira Masashi2,Tanaka Junji3,Loaëc Nadège45,Lozach Olivier4,Durieu Emilie45,Fukuda Tsutomu1,Ishibashi Fumito2,Meijer Laurent45,Iwao Masatomo1

Affiliation:

1. Division of Chemistry and Materials Sciences, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan

2. Division of Marine Life Science and Biochemistry, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan

3. Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga Koen 6-1, Kasuga 816-8580, Japan

4. Protein Phosphorylation and Human Disease Group, Station Biologique, CNRS, 29680 Roscoff, Bretagne, France

5. ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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