Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer-Reference-Cited by-同舟云学术

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

Published:2016-10-27 Issue:44 Volume:55 Page:6087-6099
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Seamon Kyle J.¹,Bumpus Namandjé N.²,Stivers James T.¹

Affiliation:

1. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, WBSB 314, Baltimore, Maryland 21205, United States

2. Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophysics 307, Baltimore, Maryland 21205, United States

Funder

American Heart Association

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.6b00986

Reference54 articles.

1. Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

2. Aicardi–Goutières syndrome and the type I interferonopathies