Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of <i>Acanthamoeba castellanii</i> CYP51-Reference-Cited by-同舟云学术

Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51

Published:2022-06-22 Issue:13 Volume:61 Page:1363-1377
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Nienhaus Karin¹^ORCID,Sharma Vandna²^ORCID,Nienhaus Gerd Ulrich¹³⁴⁵^ORCID,Podust Larissa M.²^ORCID

Affiliation:

1. Institute of Applied Physics, Karlsruhe Institute of Technology (KIT), D-76049 Karlsruhe, Germany

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, California 92093, United States

3. Institute of Nanotechnology, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany

4. Institute of Biological and Chemical Systems, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany

5. Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States

Funder

University of California, San Diego

Helmholtz Association

Center for Tropical Diseases fund

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.2c00198

Reference56 articles.

1. Sterol 14-Demethylase P450 (P45014DM*) Is One of the Most Ancient and Conserved P450 Species

2. Drug Strategies Targeting CYP51 in Neglected Tropical Diseases

3. Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

4. The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

5. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

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