DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β–γ Bridging Group of the Incoming dNTP-Reference-Cited by-同舟云学术

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β–γ Bridging Group of the Incoming dNTP

Published:2017-09-20 Issue:40 Volume:56 Page:5449-5456
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Alnajjar Khadijeh S.¹^ORCID,Negahbani Amirsoheil²,Nakhjiri Maryam²,Krylov Ivan S.²,Kashemirov Boris A.²,McKenna Charles E.²,Goodman Myron F.²,Sweasy Joann B.¹

Affiliation:

1. Department of Therapeutic Radiology and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, United States

2. Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.7b00713

Reference41 articles.

1. Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

2. Requirement of mammalian DNA polymerase-β in base-excision repair

3. Base excision repair and cancer

4. The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation

5. Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors

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