Modifying the Basicity of the dNTP Leaving Group Modulates Precatalytic Conformational Changes of DNA Polymerase β

Author:

Alnajjar Khadijeh S.1,Wang Katarina2,Alvarado-Cruz Isabel1,Chavira Cristian31ORCID,Negahbani Amirsoheil4,Nakhjiri Maryam4,Minard Corinne4,Garcia-Barboza Beatriz4,Kashemirov Boris A.4,McKenna Charles E.4ORCID,Goodman Myron F.45ORCID,Sweasy Joann B.3ORCID

Affiliation:

1. Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, United States

2. Therapeutic Radiology Department, Yale University, New Haven, Connecticut 06520, United States

3. Fred and Pamela Buffett Cancer Center and Eppley Institute for Cancer Research, Omaha, Nebraska 68198, United States

4. Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States

5. Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States

Funder

National Institute of Environmental Health Sciences

National Cancer Institute

Publisher

American Chemical Society (ACS)

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