Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator

Author:

Krumm Brian E.1,DiBerto Jeffrey F.1,Olsen Reid H. J.1,Kang Hye Jin12,Slocum Samuel T.12,Zhang Shicheng1ORCID,Strachan Ryan T.1,Huang Xi-Ping12,Slosky Lauren M.3ORCID,Pinkerton Anthony B.4ORCID,Barak Lawrence S.5,Caron Marc G.56,Kenakin Terry1,Fay Jonathan F.7ORCID,Roth Bryan L.128ORCID

Affiliation:

1. Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599-7365, United States

2. National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599-7365, United States

3. Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, United States

4. Conrad Prebys Center for Chemical Genomics at Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States

5. Department of Cell Biology, Duke University, Durham, North Carolina 27710, United States

6. Departments of Medicine and Neurobiology, Duke University, Durham, North Carolina 27710, United States

7. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States

8. Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7360, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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