Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2-Reference-Cited by-同舟云学术

Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2

Published:2021-01-19 Issue:4 Volume:60 Page:259-273
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Tararina Margarita A.¹^ORCID,Dam Katie K.²,Dhingra Manaswni²,Janda Kim D.^ORCID,Palfey Bruce A.³^ORCID,Allen Karen N.¹²^ORCID

Affiliation:

1. Program in Biomolecular Pharmacology, Boston University School of Medicine, 72 East Concord Street, Boston, Massachusetts 02118, United States

2. Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States

3. Department of Biological Chemistry, University of Michigan, 5220E MSRB III 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, United States

Funder

Division of Chemistry

National Institute of General Medical Sciences

Skaggs Institute for Chemical Biology

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.0c00855

Reference75 articles.

1. The enzymes of microbial nicotine metabolism

2. Systematic Unraveling of the Unsolved Pathway of Nicotine Degradation in Pseudomonas

3. Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16

4. Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida

5. Nicotine Decontamination of Tobacco Agro-Industrial Waste and Its Degradation by Micro-Organisms

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