A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure-Reference-Cited by-同舟云学术

A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure

Published:2019-02-05 Issue:3 Volume:30 Page:931-943
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Kesy Julita¹,Patil Kiran M.²^ORCID,Kumar Subaschandrabose Rajesh³,Shu Zhiyu²,Yong Hui Yee⁴⁵⁶,Zimmermann Louis⁷,Ong Alan Ann Lerk²,Toh Desiree-Faye Kaixin²,Krishna Manchugondanahalli S.²,Yang Lixia²,Decout Jean-Luc⁷^ORCID,Luo Dahai⁴⁵,Prabakaran Mookkan³,Chen Gang²^ORCID,Kierzek Elzbieta¹

Affiliation:

1. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland

2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore

3. Temasek Life Science Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore

4. Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, 636921, Singapore

5. NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, 636921, Singapore

6. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 636921, Singapore

7. Département de Pharmacochimie Moléculaire, University Grenoble Alpes, CNRS, ICMG FR 2607, UMR 5063, 470 Rue de la Chimie, F-38041 Grenoble, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.9b00039

Reference96 articles.

1. Self-Folding of Naked Segment 8 Genomic RNA of Influenza A Virus

2. Evolution of complementary nucleotides in 5′ and 3′ untranslated regions of influenza A virus genomic segments

3. Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle.

4. Structural features of an influenza virus promoter and their implications for viral RNA synthesis

5. Influenza Virus RNA Structure: Unique and Common Features

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