Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

Published:2015-06-10 Issue:11 Volume:26 Page:2233-2242
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

van Geel Remon¹,Wijdeven Marloes A.¹,Heesbeen Ryan¹,Verkade Jorge M. M.¹,Wasiel Anna A.¹,van Berkel Sander S.¹,van Delft Floris L.¹

Affiliation:

1. SynAffix BV, Pivot Park, Molenstraat 110, 5342 CC, Oss, The Netherlands

Funder

Technologiestichting STW

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.5b00224

Reference43 articles.

1. Himmelweit, F. (1960) The Collected Papers of Paul Ehrlich, p59, Vol.3,Pergamon,London.

2. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

3. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

4. Phase I Study of Trastuzumab-DM1, an HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer

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