Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation-Reference-Cited by-同舟云学术

Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation

Published:2021-05-24 Issue:6 Volume:32 Page:1058-1066
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Yu Wendy¹,Gillespie Kevin P.²,Chhay Bonirath¹,Svensson Anne-Sophie³,Nygren Per-Åke³,Blair Ian A.²^ORCID,Yu Feifan⁴,Tsourkas Andrew¹^ORCID

Affiliation:

1. Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

2. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

3. Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology, and Health, KTH-Royal Institute of Technology, Stockholm, Sweden and Sonia SE-100-44 Sweden

4. AlphaThera, LLC, Philadelphia, Pennsylvania 19146, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.1c00099

Reference35 articles.

1. Cytotoxic Payloads for Antibody–Drug Conjugates

2. Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development