Internal Oligoguanidinium-Based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in In Vitro and Zebrafish Model-Reference-Cited by-同舟云学术

Internal Oligoguanidinium-Based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in In Vitro and Zebrafish Model

Published:2016-09-26 Issue:10 Volume:27 Page:2254-2259
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Bhadra Jhuma¹,Pattanayak Sankha¹,Khan Pragya Paramita¹,Kundu Jayanta¹,Sinha Surajit¹

Affiliation:

1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India

Funder

Council of Scientific and Industrial Research

Department of Biotechnology , Ministry of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6b00252

Reference40 articles.

1. Morpholino Antisense Oligomers: Design, Preparation, and Properties

2. Summerton, J. and Weller, D. (1993) Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages, U.S. Patent No. 5,185,444.

3. Gene Knockdowns in Adult Animals: PPMOs and Vivo-Morpholinos

4. Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation

5. Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers

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