Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy <i>In Vitro</i>-Reference-Cited by-同舟云学术

Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro

Published:2022-12-20 Issue:1 Volume:34 Page:174-180
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Ghosh Ujjwal¹,Gupta Shalini¹,Sinha Surajit¹^ORCID

Affiliation:

1. School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, West Bengal, India

Funder

Science and Engineering Research Board

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.2c00587

Reference41 articles.

1. Morpholino antisense oligomers: the case for an RNase H-independent structural type

2. Morpholino Antisense Oligomers: Design, Preparation, and Properties

3. Invention and Early History of Morpholinos: From Pipe Dream to Practical Products

4. Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation

5. Therapeutic Strategies for Duchenne Muscular Dystrophy: An Update

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3. C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity;Organic & Biomolecular Chemistry;2023