Discovery of Bivalent GalNAc-Conjugated Betulin as a Potent ASGPR-Directed Agent against Hepatocellular Carcinoma

Author:

Yamansarov Emil Yu.123ORCID,Lopatukhina Elena V.1,Evteev Sergei A.1,Skvortsov Dmitry A.1,Lopukhov Anton V.1ORCID,Kovalev Sergey V.1ORCID,Vaneev Alexander N.12ORCID,Shkil’ Dmitry O.1ORCID,Akasov Roman A.2ORCID,Lobov Alexander N.4ORCID,Naumenko Victor A.5ORCID,Pavlova Ekaterina N.1,Ryabaya Oxana O.6,Burenina Olga Yu.7,Ivanenkov Yan A.89ORCID,Klyachko Natalia L.17ORCID,Erofeev Alexander S.12,Gorelkin Petr V.12,Beloglazkina Elena K.1,Majouga Alexander G.1210ORCID

Affiliation:

1. Lomonosov Moscow State University, Moscow 119991, Russian Federation

2. National University of Science and Technology MISiS, Moscow 119049, Russian Federation

3. Bashkir State University, Ufa 450076, Russian Federation

4. Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa 450054, Russian Federation

5. V. Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow 119034, Russian Federation

6. Department of Experimental Diagnostic and Tumor Therapy, N. N. Blokhin National Medical Research Center for Oncology, Moscow 115478, Russian Federation

7. Skolkovo Institute of Science and Technology, Skolkovo 143026, Russian Federation

8. The Federal State Unitary Enterprise Dukhov Automatics Research Institute, Moscow 127055, Russian Federation

9. Institute of Biochemistry and Genetics, Russian Academy of Science (IBG RAS) of the Ufa Federal Research Centre, Ufa 450054, Russian Federation

10. Dmitry Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russian Federation

Funder

National University of Science and Technology

Russian Science Foundation

Skolkovo Institute of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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