Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and <i>N</i>-Glycosylated Antibodies-Reference-Cited by-同舟云学术

Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies

Published:2022-03-28 Issue:4 Volume:33 Page:576-585
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Yamazoe Sayumi¹^ORCID,Kotapati Srikanth¹^ORCID,Hogan Jason M.¹,West Sean M.¹,Deng Xiaodi A.²,Diong SJ¹,Arbanas Jaren³,Nguyen Thien Anh¹,Jashnani Aarti¹^ORCID,Gupta Diksha⁴,Rajpal Arvind⁵,Dollinger Gavin¹,Strop Pavel¹⁶

Affiliation:

1. Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States

2. Dren Bio, 400 Seaport Ct, Ste 102, Redwood City, California 94063, United States

3. Discovery Biotherapeutics, Bristol-Myers Squibb, Princeton, New Jersey 08543, United States

4. SCIEX, 47370 Fremont Blvd, Fremont, California 94538, United States

5. Large Molecule Drug Discovery, Genentech, 1 DNA Way, South San Francisco, California 94080, United States

6. Biologics Discovery, Tallac Therapeutics, Burlingame, California 94010, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.1c00572

Reference32 articles.

1. Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

2. Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity

3. Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity

4. Alteration of Physicochemical Properties for Antibody-Drug Conjugates and Their Impact on Stability

5. Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload

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