Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

Published:2011-02-15 Issue:5 Volume:54 Page:1473-1480
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Qingsong¹²,Wang Jinhua¹²,Kang Seong A.³,Thoreen Carson C.¹²,Hur Wooyoung¹²,Ahmed Tausif⁴,Sabatini David M.³⁵⁶,Gray Nathanael S.¹²

Affiliation:

1. Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, United States

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, United States

3. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, United States

4. Sai Advantium Pharma Ltd., 8-2-120/86/9/B “Luxor Park”, Road No. 2, Banjara Hills, Hyderabad 500033, India

5. Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

6. Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101520v

Reference25 articles.

1. Defining the Role of mTOR in Cancer

2. Growing roles for the mTOR pathway

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4. PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways

5. mTOR and cancer: insights into a complex relationship

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