1. Department of Alzheimer’s Disease Research, National Institute for Longevity Sciences, NCGG, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan, Japan Society for the Promotion of Science (JSPS), Tokyo 102-8471, Japan, and Department of Neuroscience, Faculty of Pharmaceutical Sciences, Iwate Medical University, 2-1-1 Nishitokuda, Yahaba, Iwate 028-3694, Japan