The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology-Reference-Cited by-同舟云学术

The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology

Published:1996-10 Issue:10 Volume:2 Page:1146-1150
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Lemere Cynthia A.,Lopera Francisco,Kosik Kenneth S.,Lendon Corrine L.,Ossa Jorge,Saido Takaomi C.,Yamaguchi Haruyasu,Ruiz Andres,Martinez Alonso,Madrigal Lucia,Hincapie Liliana,Arango L. Juan Carlos,Anthony Douglas C.,Koo Edward H.,Goate Alison M.,Selkoe Dennis J.,Arango V. Juan Carlos

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1096-1146.pdf

Reference25 articles.

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2. Clark, R.F. et al. The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nature Genet. 11, 219–222 (1995).

3. Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864–870 (1996).

4. Jarrett, J.T. & Lansbury, P.T. Jr. Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73, 1055–1058 (1993).

5. Lopera, F. et al. Demencia tipo Alzheimer con agregación familiar en Antioquia, Colombia. Acta Neurol. Colombiana 10, 173–187 (1994).

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