1. Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom, and Département de Chimie Bioorganique, Faculté de Pharmacie, Institut Gilbert Laustriat, UMR 7175 CNRS, Université Louis Pasteur (Strasbourg I), 74 route du Rhin, 67400 Strasbourg-Illkirch, France