Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site
Author:
Affiliation:
1. Departments of Medicinal Chemistry, Molecular Systems, and Biological Chemistry, and X-Ray Crystallography Group, Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm960762y
Reference11 articles.
1. Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor
2. (c) A similar series of compounds that utilizes atrans-4-(aminomethyl)cyclohexylamine as well as other amines in the P1position has been claimed by Mitsubishi Chemical Co. Oshima, M.; Iware, M.; Sugiyoma, S.; Oritsu, M.; Tomao, Y.; Mounara, Y. Prolineamide Derivatives. E. P. Appl. 0699317A1, 1995.
3. A player of many parts: The spotlight falls on thrombin's structure
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