Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus

Author:

Liu Xiaoxuan12,Wu Jiangyu12,Yammine Miriam3,Zhou Jiehua2,Posocco Paola4,Viel Stephane5,Liu Cheng2,Ziarelli Fabio6,Fermeglia Maurizio4,Pricl Sabrina4,Victorero Genevieve3,Nguyen Catherine3,Erbacher Patrick7,Behr Jean-Paul8,Peng Ling1

Affiliation:

1. Aix-Marseille Université, Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UPR 3118, Département de Chimie, 163 avenue de Luminy, 13288 Marseille cedex 09, France

2. State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China

3. INSERM U928, 163 avenue de Luminy, 13288 Marseille cedex 09, France

4. Molecular Simulation Engineering (MOSE) Laboratory, Department of Chemical Engineering, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy

5. Aix-Marseille Université, LCP UMR 6264, Campus de Saint Jérôme, av. Escadrille Normandie Niémen, case 512, 13013 Marseille, France

6. Aix-Marseille Université, Fédération des Sciences Chimiques, Spectropole, av. Escadrille Normandie Niémen, case 511, 13013 Marseille, France

7. Polyplus-transfection SA, Bioparc, Boulevard S. Brandt, BP90018, 67401 Illkirch, France

8. Laboratoire de Chimie Génétique, Faculté de Pharmacie, CNRS UMR7514, 67401 Illkirch, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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