Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives

Author:

Längle Daniel1,Wojtowicz-Piotrowski Stephanie2,Priegann Till1,Keller Niklas1ORCID,Wesseler Fabian13,Reckzeh Elena S.3,Steffens Karsten1,Grathwol Christoph4,Lemke Jana4,Flasshoff Maren3,Näther Christian5ORCID,Jonson Anna C.6,Link Andreas4ORCID,Koch Oliver37,Di Guglielmo Gianni M.2,Schade Dennis18ORCID

Affiliation:

1. Department of Pharmaceutical & Medicinal Chemistry, Christian-Albrechts-University of Kiel, Gutenbergstrasse 76, 24118 Kiel, Germany

2. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London N6A 5C1, ON, Canada

3. Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany

4. Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Strasse 17, 17489 Greifswald, Germany

5. Institute of Inorganic Chemistry, Christian-Albrechts-University of Kiel, Max-Eyth-Straße 2, 24118 Kiel, Germany

6. Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, Mölndal SE-43183, Sweden

7. Institute of Pharmaceutical and Medicinal Chemistry and German Center of Infection Research, Münster 48149, Germany

8. Partner Site Kiel, DZHK, German Center for Cardiovascular Research, 24105 Kiel, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Deutsche Forschungsgemeinschaft

Cancer Research Society

Publisher

American Chemical Society (ACS)

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